Spatial pattern of intra-laminar connectivity in supragranular mouse auditory cortex

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Spatial pattern of intra-laminar connectivity in supragranular mouse auditory cortex

Neuronal responses and topographic organization of feature selectivity in the cerebral cortex are shaped by ascending inputs and by intracortical connectivity. The mammalian primary auditory cortex has a tonotopic arrangement at large spatial scales (greater than 300 microns). This large-scale architecture breaks down in supragranular layers at smaller scales (around 300 microns), where nearby ...

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BACKGROUND Radial intra- and interlaminar connections form a basic microcircuit in primary auditory cortex (AI) that extracts acoustic information and distributes it to cortical and subcortical networks. Though the structure of this microcircuit is known, we do not know how the functional connectivity between layers relates to laminar processing. METHODOLOGY/PRINCIPAL FINDINGS We studied the ...

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The role of local cortical activity in shaping neuronal responses is controversial. Among other questions, it is unknown how the diverse response patterns reported in vivo-lateral inhibition in some cases, approximately balanced excitation and inhibition (co-tuning) in others-compare to the local spread of synaptic connectivity. Excitatory and inhibitory activity might cancel each other out, or...

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ژورنال

عنوان ژورنال: Frontiers in Neural Circuits

سال: 2014

ISSN: 1662-5110

DOI: 10.3389/fncir.2014.00015